4-Bromophenol → p-Bromophenyl octyl ether

HRID 525975

반응식

HRID 525975 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Br[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 78084-BromophenolHCID 81401-BromooctaneHCID 11430Potassium Carbonate

생성물 1

HCID 145298p-Bromophenyl octyl ether수율 87.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-bromophenol (10.46 g, 60.5 mmol), 1-bromooctane (15.43 g, 79.9 mmol) and potassiumcarbonate (90 g, 0.65 mol) in N,N-dimethylformamide and was heated to 90° C. for 4 h and then the potassiumcarbonate was filtered off. The reaction mixture was quenched with water and extracted three times with ether. The ether was then washed three times with 1M hydrochloric acid (HCl), one time with water, evaporated, and purified by distillation to obtain 1-bromo-4-(octyloxy)benzene (15.1 g, 52.9 mmol) as a colourless oil.

후처리

  1. filtrationthe potassiumcarbonate was filtered off
  2. customThe reaction mixture was quenched with water
  3. extractionextracted three times with ether
  4. washThe ether was then washed three times with 1M hydrochloric acid (HCl), one time with water
  5. customevaporated
  6. distillationpurified by distillation

출처 및 근거

ORD 기록
ord-cba53612026d4ccf92bb37ba1bbffbd2
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09343198B2

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