2,2-Diphenylacetyl chloride → (R)-N5-[Amino(nitroimino)methyl]-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-N-methyl-ornithinamide

HRID 52601

반응식

HRID 52601 반응식
[NH2:1][C:2](=[N:21][N+:22]([O-:24])=[O:23])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:9]([N:11]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)[CH3:12])=[O:10])[NH2:8].[C:25]1([CH:31]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:32](Cl)=[O:33])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[NH2:1][C:2](=[N:21][N+:22]([O-:24])=[O:23])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:9]([N:11]([CH2:13][C:14]1[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=1)[CH3:12])=[O:10])[NH:8][C:32](=[O:33])[CH:31]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

참가 물질

3

반응물 2

HCID 746372,2-Diphenylacetyl chlorideHCID 136381118(R)-N5-[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N-methyl-ornithinamide

생성물 1

HCID 136381117(R)-N5-[Amino(nitroimino)methyl]-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-N-methyl-ornithinamide수율 85%

실험 절차

Prepared analogously to Example 69c) from (R)-N5 -[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N-methyl-ornithinamide and diphenylacetylchloride in a yield of 85% of theory.

출처 및 근거

ORD 기록
ord-44d88b6047eb4e58b01cfd064ab12ca2
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616620

연결된 노트

불러오는 중…