1-(4,6-Dichloro-1,5-naphthyridin-3-yl)ethan-1-one → HCID 178467144, 화합물

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Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[N:10]=2)[N:5]=[CH:4][C:3]=1[C:13](=[O:15])[CH3:14].[CH3:16][N:17]([CH2:19][C@@H:20]1[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]1)[CH3:18]>>[Cl:12][C:9]1[N:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][C:3]([C:13](=[O:15])[CH3:14])=[C:2]2[NH:26][C@H:23]1[CH2:24][CH2:25][C@@H:20]([CH2:19][N:17]([CH3:18])[CH3:16])[CH2:21][CH2:22]1

참가 물질

반응물 2

HCID 897049771-(4,6-Dichloro-1,5-naphthyridin-3-yl)ethan-1-one

HCID 178483673HCID 178483673, 화합물

생성물 1

HCID 178467144HCID 178467144, 화합물수율 55.4%

실험 절차

Following general procedure I, 1-(4,6-dichloro-1,5-naphthyridin-3-yl)ethanone (500 mg, 2.1 mmol) was reacted with cis-4-[(dimethylamino)methyl]cyclohexanamine (300 mg, 2.0 mmol) to afford the desired product (400 mg, 55%) as a yellow solid: ESI MS m/z 361 [M+H]+;

출처 및 근거

ORD 기록: ord-847fef2664794575927a90db8a6632a8
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09345709B2

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