4-[2-(Pyrrolidin-1-yl)ethyl]piperidine → HCID 117774278, 화합물

HRID 526196

반응식

HRID 526196 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[N:10]=2)[N:5]=[CH:4][C:3]=1[C:13](=[O:15])[CH3:14].[N:16]1([CH2:21][CH2:22][CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH2:20][CH2:19][CH2:18][CH2:17]1>>[Cl:12][C:9]1[N:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][C:3]([C:13](=[O:15])[CH3:14])=[C:2]2[N:26]1[CH2:25][CH2:24][CH:23]([CH2:22][CH2:21][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:28][CH2:27]1

참가 물질

3

반응물 2

HCID 2962934-[2-(Pyrrolidin-1-yl)ethyl]piperidineHCID 897049771-(4,6-Dichloro-1,5-naphthyridin-3-yl)ethan-1-one

생성물 1

HCID 117774278HCID 117774278, 화합물수율 49.1%

실험 절차

Following general procedure I, 1-(4,6-dichloro-1,5-naphthyridin-3-yl)ethanone (250 mg, 1.0 mmol) was reacted with 4-[2-(pyrrolidin-1-yl)ethyl]piperidine (230 mg, 1.3 mmol) to afford the desired product (190 mg, 47%) as a yellow solid: 1H NMR (500 MHz, CDCl3) δ 8.74 (s, 1H), 8.18 (d, J=8.8 Hz, 1H), 7.53 (d, J=8.7 Hz, 1H), 3.98-3.90 (m, 2H), 3.32-3.23 (m, 2H), 2.58-2.50 (m, 6H), 2.55 (s, 3H), 1.86-1.53 (m, 11H); ESI MS m/z 387 [M+H]+

출처 및 근거

ORD 기록
ord-6204a722db6f401c86281a861269b5a2
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09345709B2

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