Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 2-Amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 3,5-Dichlorophenylboronic acid | HCID 2734331 | — |
| 반응물 | 6-Amino-3-bromo-2-chlorobenzonitrile | HCID 54385084 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile | HCID 54101721 | 63.9% |
반응 단계
This compound was prepared in a manner analogous to that of Step D of Example 1, using 2.3 grams (0.010 mole) of 2-amino-5-bromo-6-chlorobenzonitrile (prepared as in Step A of Example 2), 2.9 grams (0.015 mole) of 3,5-dichlorophenylboronic acid, 0.1 gram (catalyst) of tetrakis(triphenylphosphine)palladium(0), and 30 mL of aqueous 2M sodium carbonate in 75 mL of toluene. The solid product was recrystallized from toluene, yielding 1.9 grams of 2-amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile. The NMR spectrum was consistent with the proposed structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05616718 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-0d644f32164c41a88910cfe52f7390a7 |
| 출처 메모 | uspto-grants-1997_04 |