Dimethylformamide diethylacetal → Ethyl 3-(dimethylamino)-2-(4-(trifluoromethyl)phenyl)acrylate

HRID 526404노트

반응식

HRID 526404 반응식
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:5][CH:4]=1.C(O[CH:20](OCC)[N:21]([CH3:23])[CH3:22])C>>[CH3:20][N:21]([CH3:23])[CH:22]=[C:9]([C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:15])([F:16])[F:1])=[CH:8][CH:7]=1)[C:10]([O:12][CH2:13][CH3:14])=[O:11]

참가 물질

3

반응물 2

HCID 70913Dimethylformamide diethylacetalHCID 14134124Ethyl (4-(trifluoromethyl)phenyl)acetate

생성물 1

HCID 131732876Ethyl 3-(dimethylamino)-2-(4-(trifluoromethyl)phenyl)acrylate

실험 절차

The title compound was prepared in a manner similar to Example Preparation 10 using ethyl 2-(4-(trifluoromethyl)phenyl)acetate and 1,1-diethoxy-N,N-dimethylmethanamine to give the title compound. 1H NMR (400 MHz, chloroform-d) δ ppm 1.21 (t, J=7.1 Hz, 3H) 2.71 (s, 6H) 4.14 (q, J=7.2 Hz, 2H) 7.31 (d, J=7.8 Hz, 2H) 7.53 (d, J=7.8 Hz, 2H) 7.61 (s, 1H).

출처 및 근거

ORD 기록
ord-c648425b95c14a5397f96a2c924d85a4
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09345713B2

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