Trifluoroacetic acid → HCID 131732882, 화합물

HRID 526446

반응식

HRID 526446 반응식
[CH2:1]([NH:8][C:9](=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([NH:16][NH2:17])=N[CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CN(C)[CH:21]=[C:22]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1)[C:23]([O:25][CH3:26])=[O:24].[C:34](O)(C(F)(F)F)=O>C(O)C.CCOC(C)=O>[CH2:1]([NH:8][C:9]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][NH:17][CH:21]=[C:22]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)[C:23]([O:25][CH3:26])=[O:24])=[CH:34][CH:11]=1)=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 6422Trifluoroacetic acidHCID 51370238N-benzyl-6-hydrazinylpyridine-3-carboxamideHCID 73047442Methyl 3-(dimethylamino)-2-(2-pyridinyl)-2-propenoate

생성물 1

HCID 131732882HCID 131732882, 화합물수율 73.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

Combined N-benzyl-6-hydrazinylnicotinamide (200 mg, 0.826 mmol), methyl 3-(dimethylamino)-2-(pyridin-2-yl)acrylate (170 mg, 0.826 mmol) and TFA (0.127 mL, 1.651 mmol) in ethanol (3 mL) and stirred overnight at room temperature. The reaction mixture was diluted in EtOAc (50 mL), washed with saturated aqueous sodium bicarbonate (20 ml), brine (20 ml), dried with Na2SO4 and concentrated to give the title compound (244 mg) as an orange solid, was used without further purification. MS m/z [M+H]+ 404.4.

후처리

  1. washwashed with saturated aqueous sodium bicarbonate (20 ml), brine (20 ml)
  2. dry with materialdried with Na2SO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fb94b72e70be42fabc156342cd64610e
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09345713B2

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