1-(Methoxymethyl)cyclopropan-1-amine hydrochloride → HCID 178494694, 화합물

HRID 526525노트

반응식

HRID 526525 반응식
[OH:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([O:22][CH3:23])[CH:17]=1.Cl.[CH3:25][O:26][CH2:27][C:28]1([NH2:31])[CH2:30][CH2:29]1>>[OH:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([NH:31][C:28]3([CH2:27][O:26][CH3:25])[CH2:30][CH2:29]3)=[O:13])=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([O:22][CH3:23])[CH:17]=1

참가 물질

3

반응물 2

HCID 534072301-(Methoxymethyl)cyclopropan-1-amine hydrochlorideHCID 178487655HCID 178487655, 화합물

생성물 1

HCID 178494694HCID 178494694, 화합물

실험 절차

The title compound was prepared in a manner similar to Example 198 using 6-(5-hydroxy-4-(2-methoxypyridin-4-yl)-1H-pyrazol-1-yl)nicotinic acid and 1-(methoxymethyl)cyclopropanamine hydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.80 (s, 4H) 3.28 (s, 3H) 3.48 (s, 2H) 3.90 (s, 3H) 7.49 (br. s., 1H) 7.57 (d, J=5.3 Hz, 1H) 8.08 (d, J=5.6 Hz, 1H) 8.35-8.50 (m, 2H) 8.68 (br. s., 1H) 8.90 (t, J=1.4 Hz, 1H) 8.98 (s, 1H). MS m/z 396 [M+H]+.

출처 및 근거

ORD 기록
ord-4c1a10d8870649b68444a303249f92b6
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09345713B2

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