Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(R)-(+)-1-Boc-3-aminopyrrolidine → (R)-((S)-tetrahydrofuran-3-yl) 3-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)pyrrolidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (R)-(+)-1-Boc-3-aminopyrrolidine | HCID 854070 | — |
| 반응물 | Carbonic Acid 2,5-Dioxopyrrolidin-1-yl (S)-Tetrahydrofuran-3-yl Ester | HCID 11229944 | — |
| 반응물 | (S)-2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-(1-(methylsulfonyl)pyrrolidin-3-yl)pyrimidin-4-amine | HCID 68008525 | — |
| 생성물 | (R)-((S)-tetrahydrofuran-3-yl) 3-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)pyrrolidine-1-carboxylate | HCID 68007886 | 47% |
반응 단계
According to the procedure for compound 398 using (R)-tert-butyl 3-aminopyrrolidine-1-carboxylate and (S)-2,5-dioxopyrrolidin-1-yl tetrahydrofuran-3-yl carbonate afforded 19.8 mg (47% yield) of 424 as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09345708B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-e39f8134e463413cbe90d9547f34e926 |
| 출처 메모 | uspto-grants-2016_05 |