Ammonium Hydroxide → 2-Amino-1-methylcyclohexan-1-ol

HRID 526967

반응식

HRID 526967 반응식
[CH3:1][C:2]12[O:8][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3]2.[OH-].[NH4+:10]>O>[NH2:10][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1([CH3:1])[OH:8]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 2242431-Methyl-1,2-epoxycyclohexane2회

생성물 1

HCID 203650302-Amino-1-methylcyclohexan-1-ol

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
50 °C

실험 절차

To a solution of 1-methyl-7-oxabicyclo[4.1.0]heptane, 30a, (1.0 g, 7.1 mmol) in water was added ammonium hydroxide (6.0 mL, 154.1 mmol). The mixture was heated to 50° C. for 48 hours. The mixture was diluted with water, extracted with EtOAc and then twice with 20% MeOH/CHCl3. The organic phases were dried (MgSO4), filtered and concentrated in vacuo to provide the desired product, 30b, as an amorphous white solid.

후처리

  1. extractionextracted with EtOAc
  2. dry with materialThe organic phases were dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-b67315c040f44fbba5c5f73e9b24f4e5
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09345708B2

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