HCID 131731865, 화합물 → HCID 67291290, 화합물
반응식
[N:1]([CH:4]1[CH2:9][CH2:8][CH2:7][CH:6]([O:10][CH3:11])[CH:5]1[O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])=[N+]=[N-]>C(OCC)(=O)C.[Pd]>[NH2:1][CH:4]1[CH2:9][CH2:8][CH2:7][CH:6]([O:10][CH3:11])[CH:5]1[O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]참가 물질
4
실험 절차
A solution of racemic [1-Azido-3-methoxy-2-cyclohexanoxy]tert-butyl-dimethylsilane, 51g, (2.57 g; 6.3 mmol) in 20 mL of ethyl acetate was hydrogenated with Pd—C 10% (5 mole %; Degussa) at 45 PSI in a Parr hydrogenation apparatus for 1 h. The reaction mixture was filtered over a nylon and glass fiber filter and concentrated in vacuo to provide 2.32 g of the desired product 51h as a white solid.
후처리
- filtrationThe reaction mixture was filtered over a nylon and glass fiber
- filtrationfilter
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-af92dec5eeda4442b8eb5f38fb1ff203
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09345708B2
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