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Sodium Iodide → HCID 86717343, 화합물

HRID 527137
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HRID 527137 반응식
Cl[C:2]1([C:13]2[CH:18]=[CH:17][C:16]([CH:19]([CH3:21])[CH3:20])=[CH:15][C:14]=2[O:22][CH3:23])[C:10](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:12].[I-].[Na+].[N-:26]=[N+:27]=[N-:28].[Na+]>CC(C)=O>[N:26]([C:2]1([C:13]2[CH:18]=[CH:17][C:16]([CH:19]([CH3:21])[CH3:20])=[CH:15][C:14]=2[O:22][CH3:23])[C:10](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:12])=[N+:27]=[N-:28]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 5238Sodium IodideHCID 33557Sodium AzideHCID 86717344HCID 86717344, 화합물

생성물 1

HCID 86717343HCID 86717343, 화합물수율 99,396.703%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
80 °C

실험 절차

To a solution of 2-chloro-2-(4-isopropyl-2-methoxyphenyl)-1H-inden-1,3(2H)-dione (0.10 g, 0.3 mmol) in acetone (5 ml) were added with sodium iodide (54 mg, 0.36 mmol) and sodium azide (50 mg, 0.76 mmol) and distilled water (1 ml), followed by stirring at 80° C. for 6 hrs. The reaction mixture was added water, and extracted diethyl ether, and washed with water and brine in that order. The washed organic layer was concentrated to afford the title compound (100 g, 98%).

후처리

  1. distillationdistilled water (1 ml)
  2. additionThe reaction mixture was added water
  3. extractionextracted diethyl ether
  4. washwashed with water and brine in that order
  5. concentrationThe washed organic layer was concentrated

출처 및 근거

ORD 기록
ord-6816e6c7cc9f48f6b9e1752cf723252c
출처 데이터셋
uspto-grants-2016_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09346749B2

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