Water → HCID 90323117, 화합물

HRID 527198노트

반응식

HRID 527198 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)[NH2:5].N1C=CC=CC=1.Cl[C:30]([O:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:31].O>C(#N)C>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:30](=[O:31])[O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:6]=[CH:7][C:8]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 15891Phenyl chloroformateHCID 176097133-Fluoro-4-(4-(4-methoxyphenyl)piperazin-1-yl)aniline

생성물 1

HCID 90323117HCID 90323117, 화합물수율 83%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 4 (0.32 g, 1 mmol) and pyridine (0.12 mL, 1.5 mmol) in acetonitrile (4 mL, 0.25M), phenyl chloroformate (0.16 mL, 1.2 mmol) was added at 0° C. and the reaction mixture was stirred at room temperature for overnight. Then water was added and the mixture was stirred for 30 min. The precipitated white solid was filtered and the solid was washed with acetonitrile and then dried under vacuum to obtain compound 5 (0.35 g, 83%).

후처리

  1. stirringthe mixture was stirred for 30 min
  2. filtrationThe precipitated white solid was filtered
  3. washthe solid was washed with acetonitrile
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-29b926f63f0c4de9b259f4ef280dc876
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346791B2

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