Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 527280생성일: 2026년 10월 25일
Piperidine → 3-((3-chlorophenyl)amino)-5-((4-fluoro-2-methylbenzyl)amino)-1H-pyrazole-4-carbonitrile
https://huagongshe.com/reaction/527280
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 4-Fluoro-2-methylbenzaldehyde | HCID 2783217 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 5-Amino-3-(3-chloro-phenylamino)-4-cyano-pyrazole | HCID 10681167 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-((3-chlorophenyl)amino)-5-((4-fluoro-2-methylbenzyl)amino)-1H-pyrazole-4-carbonitrile | HCID 178427852 | — |
반응 단계
Dissolved 5-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carbonitrile (58 mg) in 4 mL ethanol and added 0.250 mmol of 4-fluoro-2-methylbenzaldehyde followed by a single drop of piperidine. This solution was then heated to 85° C. for 17 hrs, then the ethanol was evaporated and the resulting product was scraped from the reaction vessels. The powder was then resuspended in 4 mL of MeOH and 3 eq. of sodium borohydride was added and left stirring overnight at room temperature. Then MeOH was then evaporated and the product C29 was scraped and collected. (50 mg)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09346792B2 |
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| 출처 데이터셋 | uspto-grants-2016_05 |
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| ORD ID | ord-878f3cb77382442faf75abf953936ae6 |
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| 출처 메모 | uspto-grants-2016_05 |
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