2-(4-(Methylthio)benzyl)isoindoline-1,3-dione → 2-(5-Methylsulfanyl-pyridin-2-ylmethyl)-isoindole-1,3-dione

반응식

[CH3:1][S:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[C:16](=[O:17])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:18])=C[CH:4]=1.CSC1C=CC(NC)=[N:27]C=1>>[CH3:1][S:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[C:16](=[O:17])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:18])=[N:27][CH:4]=1

참가 물질

반응물 2

HCID 79600652-(4-(Methylthio)benzyl)isoindoline-1,3-dione

HCID 68974266(5-Methylsulfanyl-pyridin-2-yl)-methylamine

생성물 1

HCID 867116242-(5-Methylsulfanyl-pyridin-2-ylmethyl)-isoindole-1,3-dione

실험 절차

The title compound is prepared in analogy to preparation 6a, substituting 4-(methylthio)-benzylamine with (5-methylsulfanyl-pyridin-2-yl)-methylamine (preparation 16a). ESI mass spectrum: [M+H]+=285; r.t. HPLC: 0.51 min (X012_S01).

후처리

customr.t
custom0.51 min (X012_S01)

출처 및 근거

ORD 기록: ord-7cc8766b50384fd7b23d32f05d907c26
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09346794B1

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