4-Fluorophenyl chloroformate → HCID 53247232, 화합물

HRID 527476

반응식

HRID 527476 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:13]([NH:14][CH:15]([CH3:17])[CH3:16])[CH2:12][N:11]([C:18]([CH:20]3[CH2:25][CH2:24][N:23]([C:26]([C:28]4([CH3:31])[CH2:30][CH2:29]4)=[O:27])[CH2:22][CH2:21]3)=[O:19])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl[C:33]([O:35][C:36]1[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=1)=[O:34]>>[F:42][C:39]1[CH:40]=[CH:41][C:36]([O:35][C:33](=[O:34])[N:14]([C@H:13]2[C@H:9]([C:4]3[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=3)[CH2:10][N:11]([C:18]([CH:20]3[CH2:25][CH2:24][N:23]([C:26]([C:28]4([CH3:31])[CH2:30][CH2:29]4)=[O:27])[CH2:22][CH2:21]3)=[O:19])[CH2:12]2)[CH:15]([CH3:16])[CH3:17])=[CH:37][CH:38]=1

참가 물질

3

반응물 2

HCID 27332564-Fluorophenyl chloroformateHCID 67239261rac-[(3R,4S)-3-(3,4-Dichloro-phenyl)-4-isopropylamino-pyrrolidin-1-yl]-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yl]-methanone

생성물 1

HCID 53247232HCID 53247232, 화합물

실험 절차

In analogy to the procedure described for the synthesis of example 1 (step h), the title compound rac-{(3S,4R)-4-(3,4-dichloro-phenyl)-1-[1-(1-methyl-cyclopropanecarbonyl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-isopropyl-carbamic acid 4-fluoro-phenyl ester was prepared from rac-[(3R,4S)-3-(3,4-Dichloro-phenyl)-4-isopropylamino-pyrrolidin-1-yl]-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yl]-methanone instead of rac-{4-[(3S,4R)-3-(3,4-dichloro-phenyl)-4-methylamino-pyrrolidine-1-carbonyl]-piperidin-1-yl}-(1-methyl-cyclopropyl)-methanone using 4-fluorophenyl chloroformate and was obtained as a colorless foam. MS m/e: 604.3 [M]+.

후처리

  1. customIn analogy to the procedure described for the synthesis of example 1 (step h)
  2. customwas obtained as a colorless foam

출처 및 근거

ORD 기록
ord-9733060ec326411791bc38bf74b717d0
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346786B2

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