Stannous chloride dihydrate → 6-[(3-Ethyl-1,2-benzisoxazol-4-yl)oxy]-3-pyridinamine

HRID 527528노트

반응식

HRID 527528 반응식
[CH2:1]([C:3]1[C:7]2[C:8]([O:12][C:13]3[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][N:14]=3)=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][N:4]=1)[CH3:2].O.O.[Sn](Cl)Cl>C(O)C>[CH2:1]([C:3]1[C:7]2[C:8]([O:12][C:13]3[N:14]=[CH:15][C:16]([NH2:19])=[CH:17][CH:18]=3)=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][N:4]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 61436Stannous chloride dihydrateHCID 679599933-Ethyl-4-[(5-nitro-2-pyridinyl)oxy]-1,2-benzisoxazole2회

생성물 1

HCID 679605196-[(3-Ethyl-1,2-benzisoxazol-4-yl)oxy]-3-pyridinamine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

3-ethyl-4-[(5-nitro-2-pyridinyl)oxy]-1,2-benzisoxazole (Intermediate 32, 9 mg) was dissolved in 3.0 ml of ethanol. Then tin(II) chloride dihydrate (21.4 mg, 0.095 mmol) was added and the reaction mixture was stirred at 80° C. for 3 hours. After quenching with water and extraction with ethyl acetate, the organic phase was dried over sodium sulphate, filtered and evaporated to afford the title compound.

후처리

  1. customAfter quenching with water and extraction with ethyl acetate
  2. dry with materialthe organic phase was dried over sodium sulphate
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-c13be8d01eee4b52a91eb1aa757d30bb
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346790B2

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