1-Bromo-4-chlorobutane → 9-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amine

HRID 527800노트

반응식

HRID 527800 반응식
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]1[N:11]=[C:12]2[C:17]([N:18]=1)=[C:16]([NH2:19])[NH:15][C:14]([O:20][C@@H:21]([CH3:24])[CH2:22][CH3:23])=[N:13]2.Br[CH2:26][CH2:27][CH2:28][CH2:29][Cl:30]>C(OCC)(=O)C.C1CCCCC1>[Cl:30][CH2:29][CH2:28][CH2:27][CH2:26][N:11]1[C:10]([O:9][CH3:8])=[N:18][C:17]2[C:12]1=[N:13][C:14]([O:20][C@@H:21]([CH3:24])[CH2:22][CH3:23])=[N:15][C:16]=2[NH2:19]

참가 물질

4

반응물 2

HCID 813641-Bromo-4-chlorobutaneHCID 178456042HCID 178456042, 화합물

생성물 1

HCID 592526489-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amine

시약·촉매·용매 1

HCID 21867204Cyclohexane ethylacetate용매

실험 절차

Prepared similarly to Intermediate 18 from 8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-1H-purin-6-amine trifluoroacetate and 1-bromo-4-chlorobutane with purification on an aminopropyl (NH2) cartridge using a 0-100% ethyl acetate-cyclohexane gradient.

출처 및 근거

ORD 기록
ord-8862171c81e44b68b0f981b6c2e5d3cd
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346806B2

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