1-Bromo-4-chlorobutane → 9-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpentyl]oxy}-9H-purin-6-amine

HRID 527805노트

반응식

HRID 527805 반응식
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]1[N:11]=[C:12]2[C:17]([N:18]=1)=[C:16]([NH2:19])[NH:15][C:14]([O:20][C@@H:21]([CH3:26])[CH2:22][CH2:23][CH2:24][CH3:25])=[N:13]2.Br[CH2:28][CH2:29][CH2:30][CH2:31][Cl:32]>>[Cl:32][CH2:31][CH2:30][CH2:29][CH2:28][N:11]1[C:10]([O:9][CH3:8])=[N:18][C:17]2[C:12]1=[N:13][C:14]([O:20][C@@H:21]([CH3:26])[CH2:22][CH2:23][CH2:24][CH3:25])=[N:15][C:16]=2[NH2:19]

참가 물질

3

반응물 2

HCID 813641-Bromo-4-chlorobutaneHCID 178445909HCID 178445909, 화합물

생성물 1

HCID 592525559-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpentyl]oxy}-9H-purin-6-amine

실험 절차

Prepared similarly to Intermediate 44 from 8-(methyloxy)-2-{[(1S)-1-methylpentyl]oxy}-1H-purin-6-amine trifluoroacetate and 1-bromo-4-chlorobutane.

출처 및 근거

ORD 기록
ord-696c6da05cab4f5a89074e4132b6ca7a
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346806B2

반응 노트

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