1-Bromo-5-chloropentane → 9-(5-Chloropentyl)-2-[(1-methylethyl)oxy]-8-(methyloxy)-9H-purin-6-amine

반응식

FC(F)(F)C(O)=O.[CH3:8][CH:9]([O:11][C:12]1[NH:13][C:14]([NH2:23])=[C:15]2[C:19]([N:20]=1)=[N:18][C:17]([O:21][CH3:22])=[N:16]2)[CH3:10].Br[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][Cl:30]>>[Cl:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][N:18]1[C:17]([O:21][CH3:22])=[N:16][C:15]2[C:19]1=[N:20][C:12]([O:11][CH:9]([CH3:8])[CH3:10])=[N:13][C:14]=2[NH2:23]

참가 물질

반응물 2

HCID 960701-Bromo-5-chloropentane

HCID 178494011HCID 178494011, 화합물

생성물 1

HCID 592526339-(5-Chloropentyl)-2-[(1-methylethyl)oxy]-8-(methyloxy)-9H-purin-6-amine

실험 절차

Prepared similarly to Intermediate 44 from 2-[(1-methylethyl)oxy]-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 1-bromo-5-chloropentane.

출처 및 근거

ORD 기록: ord-967354e89f4d44288ef9de3555f0fd48
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09346806B2

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