1-Bromo-4-chlorobutane → 9-(4-chlorobutyl)-2-(cyclohexyloxy)-8-(methyloxy)-9H-purin-6-amine

반응식

FC(F)(F)C(O)=O.[CH:8]1([O:14][C:15]2[NH:16][C:17]([NH2:26])=[C:18]3[C:22]([N:23]=2)=[N:21][C:20]([O:24][CH3:25])=[N:19]3)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.Br[CH2:28][CH2:29][CH2:30][CH2:31][Cl:32]>>[Cl:32][CH2:31][CH2:30][CH2:29][CH2:28][N:21]1[C:20]([O:24][CH3:25])=[N:19][C:18]2[C:22]1=[N:23][C:15]([O:14][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1)=[N:16][C:17]=2[NH2:26]

참가 물질

반응물 2

HCID 813641-Bromo-4-chlorobutane

HCID 178494008HCID 178494008, 화합물

생성물 1

HCID 592526519-(4-chlorobutyl)-2-(cyclohexyloxy)-8-(methyloxy)-9H-purin-6-amine

실험 절차

Prepared similarly to Intermediate 44 from 2-(cyclohexyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 1-bromo-4-chlorobutane.

출처 및 근거

ORD 기록: ord-e3c484cfbf454289823c2d634675c983
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09346806B2

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