Piperidine → 6-Amino-2-{[(1S)-1-methylpentyl]oxy}-9-[4-(1-piperidinyl)butyl]-7,9-dihydro-8H-purin-8-one

반응식

Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]([O:15]C)=[N:13][C:12]2[C:7]1=[N:8][C:9]([O:18][C@@H:19]([CH3:24])[CH2:20][CH2:21][CH2:22][CH3:23])=[N:10][C:11]=2[NH2:17].[NH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[NH2:17][C:11]1[N:10]=[C:9]([O:18][C@@H:19]([CH3:24])[CH2:20][CH2:21][CH2:22][CH3:23])[N:8]=[C:7]2[C:12]=1[NH:13][C:14](=[O:15])[N:6]2[CH2:5][CH2:4][CH2:3][CH2:2][N:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1

참가 물질

반응물 2

HCID 8082Piperidine

HCID 592525559-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpentyl]oxy}-9H-purin-6-amine

생성물 1

HCID 592526126-Amino-2-{[(1S)-1-methylpentyl]oxy}-9-[4-(1-piperidinyl)butyl]-7,9-dihydro-8H-purin-8-one

실험 절차

Prepared similarly to Example 29 from 9-(4-chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpentyl]oxy}-9H-purin-6-amine and piperidine.

출처 및 근거

ORD 기록: ord-f5abae8aacfb4a35b9092ca38617ccba
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09346806B2

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