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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 527878생성일: 2026년 10월 26일

8-Boc-3,8-diaza-bicyclo(3.2.1)octane → 3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/527878

반응식

참여 물질

역할이름HCID투입량
반응물8-Boc-3,8-diaza-bicyclo(3.2.1)octaneHCID 15740908—
반응물tert-Butyl 4,7-diazaspiro(2.5)octane-4-carboxylateHCID 51358567—
반응물7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-carboxylic acid tert-butyl esterHCID 57477280—
생성물3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl esterHCID 57477265—

반응 단계

Prepared in a way similar to Intermediate 1, using 3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester, instead of 4,7-diaza-spiro[2.5]octane-4-carboxylic acid tert-butyl ester.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09346809B2
출처 데이터셋uspto-grants-2016_05
ORD IDord-480b82ed36624265aaf7d516d070a956
출처 메모uspto-grants-2016_05