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Triethylamine → 7-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diaza-spiro[2.5]octane-4-sulfonic acid (2-cyano-ethyl)-methyl-amide

HRID 527892
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인쇄 미리보기

반응식

HRID 527892 반응식
CC(C)(C(=O)[N:6]1[CH:11]2[CH2:12][CH2:13][CH:7]1[CH2:8][N:9]([C:14]1[C:15]3[CH:22]=[CH:21][NH:20][C:16]=3[N:17]=[CH:18][N:19]=1)[CH2:10]2)C#N.C(N(CC)CC)C.[C:32]([CH2:34][CH2:35][N:36]([CH3:41])[S:37](Cl)(=[O:39])=[O:38])#[N:33]>C1COCC1>[C:32]([CH2:34][CH2:35][N:36]([CH3:41])[S:37]([N:6]1[CH2:7][CH2:8][N:9]([C:14]2[C:15]3[CH:22]=[CH:21][NH:20][C:16]=3[N:17]=[CH:18][N:19]=2)[CH2:10][C:11]21[CH2:12][CH2:13]2)(=[O:39])=[O:38])#[N:33]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 167697832-Cyanoethyl(methyl)sulfamoyl chlorideHCID 668883222,2-Dimethyl-3-oxo-3-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-propionitrile

생성물 1

HCID 668994747-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diaza-spiro[2.5]octane-4-sulfonic acid (2-cyano-ethyl)-methyl-amide

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

Intermediate 2 (0.05 mmol) was dissolved in THF (1.0 mL). Triethylamine (0.12 mmol) and 2-cyanoethyl(methyl)sulfamoyl chloride (0.06 mmol) was added. The reaction mixture was left at it for 16 hours. The pure compounds were obtained by standard preparative HPLC purification of the reaction mixture.

후처리

  1. customThe pure compounds were obtained by standard preparative HPLC purification of the reaction mixture

출처 및 근거

ORD 기록
ord-bc475b75b06d44b1b495017d51fc0841
출처 데이터셋
uspto-grants-2016_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09346809B2

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