Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 527921생성일: 2026년 10월 25일
Water → (R)-N-methyl-N-(4-(methylsulfonyl)phenyl)-1-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine
https://huagongshe.com/reaction/527921
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Fluoro-4-(methylsulphonyl)benzene | HCID 67994 | — |
| 반응물 | (R)-N-methyl-1-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine | HCID 66765875 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (R)-N-methyl-N-(4-(methylsulfonyl)phenyl)-1-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine | HCID 68027352 | — |
반응 단계
A mixture of (R)—N-methyl-1-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine (100 mg, 0.287 mmol) and 1-fluoro-4-(methylsulfonyl)benzene (150 mg, 0.861 mmol) and K2CO3 (158 mg, 1.142 mmol) in DMF (2 mL) was stirred at 120° C. overnight and then cooled to ambient temperature, poured into water, and extracted with EtOAc. The EtOAc layer was concentrated, purified by preparative TLC to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09346810B2 |
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| 출처 데이터셋 | uspto-grants-2016_05 |
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| ORD ID | ord-8a6e48e266ee4ea581f1d4ab95eb4a3c |
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| 출처 메모 | uspto-grants-2016_05 |
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