Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 527933생성일: 2026년 10월 26일
Sodium Azide → (R)-N-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)-N-methyl-5-(2H-tetrazol-5-yl)pyridin-2-amine
https://huagongshe.com/reaction/527933
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | Ammonia chloride | HCID 20976574 | — |
| 반응물 | (R)-6-((1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)(methyl)amino)nicotinonitrile | HCID 66765754 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (R)-N-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)-N-methyl-5-(2H-tetrazol-5-yl)pyridin-2-amine | HCID 86692153 | — |
반응 단계
A mixture of (R)-6-((1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)(methyl)amino)nicotinonitrile (100 mg, 0.3 mmol), ammonia chloride (84 mg, 1.57 mmol) and sodium azide (108 mg, 1.66 mmol) in N,N-dimethylformamide (5.0 mL) was stirred at 120° C. for 16 h. The volatile was removed under vacuum and the residue was purified by chromatography on silica gel to give the title compound. MS (m/z): 363.0 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09346810B2 |
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| 출처 데이터셋 | uspto-grants-2016_05 |
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| ORD ID | ord-ba07618c7dca45be825a729a72254b9b |
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| 출처 메모 | uspto-grants-2016_05 |
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