Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 528생성일: 2026년 10월 23일
Ethyl 4-piperidinecarboxylate → Ethyl 1-(6-chloro-4-methyl-3-pyridinyl)piperidine-4-carboxylate
https://huagongshe.com/ko/reaction/528
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| 반응물 | 5-Bromo-2-chloro-4-methylpyridine | HCID 2734427 | — |
| 시약 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | Palladium (II) acetate | HCID 4144353 | — |
| 촉매 | 2-Dicyclohexylphosphino-2',6'-diisopropoxybiphenyl | HCID 16217985 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 1-(6-chloro-4-methyl-3-pyridinyl)piperidine-4-carboxylate | HCID 82225133 | 0% |
반응 단계
A solution of diacetoxypalladium (10.87 mg, 0.05 mmol) and dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine (45.2 mg, 0.10 mmol) dissolved in toluene (3 mL) was degassed and heated to 50°C for 30 minutes before adding ethyl piperidine-4-carboxylate (0.105 mL, 0.68 mmol), 5-bromo-2-chloro-4-methylpyridine (100 mg, 0.48 mmol) and sodium 2-methylpropan-2-olate (74.5 mg, 0.77 mmol) under nitrogen. The mixture was heated to 100°C for 2 hours. LCMS indicated little product so reaction abandoned.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-e4f50ecc5cb146dc9c3dbbd5fbb158a0 |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
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