1H-Indazol-6-amine → N2,N4-bis(6-indazolyl)-5-ethoxycarbonyl-2,4-primidinediamine

HRID 528157

반응식

HRID 528157 반응식
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][N:3]=1.[NH2:14][C:15]1[CH:23]=[C:22]2[C:18]([CH:19]=[N:20][NH:21]2)=[CH:17][CH:16]=1>>[NH:21]1[C:22]2[C:18](=[CH:17][CH:16]=[C:15]([NH:14][C:2]3[N:7]=[C:6]([NH:14][C:15]4[CH:23]=[C:22]5[C:18]([CH:19]=[N:20][NH:21]5)=[CH:17][CH:16]=4)[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][N:3]=3)[CH:23]=2)[CH:19]=[N:20]1

참가 물질

3

반응물 2

HCID 814231H-Indazol-6-amineHCID 104020Ethyl 2,4-dichloropyrimidine-5-carboxylate

생성물 1

HCID 22060443N2,N4-bis(6-indazolyl)-5-ethoxycarbonyl-2,4-primidinediamine

실험 절차

In like manner to N2,N4-bis(3-hydroxyphenyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine, 2,4-dichloro-5-ethoxycarbonylpyrimidine and 6-aminoindazole were reacted to yield N2,N4-bis(6-indazolyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine. 1H NMR (DMSO-d6): δ 8.76 (s, 1H), 7.73 (d, 2H J=8.8), 7.54 (m, 4H), 7.36 (d, 2H, J=9.5 Hz), 4.3 (q, 2H, J=7.0 Hz), 1.34 (3H, J=7 Hz); LCMS: ret. time 27.59 min.; purity: 95%; MS (m/e): 415 (MH+).

출처 및 근거

ORD 기록
ord-4f4f6c3d25fd44219cd07b077dea060c
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346765B2

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