1H-indazol-7-amine → N2,N4-bis(7-indazolyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine

HRID 528158

반응식

HRID 528158 반응식
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][N:3]=1.[NH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:23]=1[NH:22][N:21]=[CH:20]2>>[NH:22]1[C:23]2[C:19](=[CH:18][CH:17]=[CH:16][C:15]=2[NH:14][C:2]2[N:7]=[C:6]([NH:14][C:15]3[CH:16]=[CH:17][CH:18]=[C:19]4[C:23]=3[NH:22][N:21]=[CH:20]4)[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][N:3]=2)[CH:20]=[N:21]1

참가 물질

3

반응물 2

HCID 889011H-indazol-7-amineHCID 104020Ethyl 2,4-dichloropyrimidine-5-carboxylate

생성물 1

HCID 22060714N2,N4-bis(7-indazolyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine

실험 절차

In like manner to N2,N4-bis(3-hydroxyphenyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine, 2,4-dichloro-5-ethoxycarbonylpyrimidine and 7-aminoindazole were reacted to yield N2,N4-bis(7-indazolyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine. 1H NMR (DMSO-d6): δ 8.70 (s, 1H), 7.54 (d, 2H J=8.4 Hz), 7.37 (m, 6H), 4.3 (q, 2H, J=7.0 Hz), 1.33 (3H, J=7 Hz); LCMS: ret. time 23.61 min.; purity: 94%; MS (m/e): 415 (MH+).

출처 및 근거

ORD 기록
ord-b1507e5e1f544a309f9d111b3ccba7f5
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346765B2

연결된 노트

불러오는 중…