Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Methyl-2-pyridylmethanol → HCID 70051254, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Methyl-2-pyridylmethanol | HCID 70736 | — |
| 반응물 | Valine methyl ester | HCID 94285 | — |
| 반응물 | Isocyanate | HCID 105034 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | HCID 70051254 | HCID 70051254 | — |
반응 단계
To a solution of the isocyanate derived from Valine methyl ester (17.9 mmol) dissolved in toluene was added 6-methyl-pyridine-2-methanol (2.42 g, 1.1 equivalent). The solution was he ated at reflux for 2 hours. After concentration in vacuo and purifiction by silica gel column chromatography, (6-methylpyridin-2-yl)methoxycarbonyl-Valine methyl ester (2.8 g) was obtained. Hydrolysis of the methyl ester using aqueous lithium hydroxide provide the title compound upon recrystallization from hot ethyl acetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05616714 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-283d8e917d9a4c03a44e8ad967461067 |
| 출처 메모 | uspto-grants-1997_04 |