반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][O:15][C:14]2[CH:18]=[C:19]([S:22](Cl)(=[O:24])=[O:23])[CH:20]=[CH:21][C:13]1=2.[S:26]1[CH:30]=[CH:29][N:28]=[C:27]1[NH2:31]>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][O:15][C:14]2[CH:18]=[C:19]([S:22]([NH:31][C:27]3[S:26][CH:30]=[CH:29][N:28]=3)(=[O:24])=[O:23])[CH:20]=[CH:21][C:13]1=2참가 물질
3
실험 절차
4-(2-Chloro-4-(trifluoromethyl)phenyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide (EXAMPLE 5) was prepared in the same manner as INTERMEDIATE D, step 3, starting from 4-(2-chloro-4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride and using thiazol-2-amine instead of intermediate A. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.73 (br. s., 2 H) 4.36 (t, J=4.45 Hz, 2 H) 6.32 (d, J=8.41 Hz, 1 H) 6.79 (d, J=4.50 Hz, 1 H) 7.14 (dd, J=8.61, 2.15 Hz, 1 H) 7.17-7.26 (m, 2 H) 7.73 (d, J=8.31 Hz, 1 H) 7.81-7.88 (m, 1 H) 8.06 (s, 1 H) 12.58 (br. s., 1 H).
출처 및 근거
- ORD 기록
- ord-19fae85b9c9e443e8fc4b7edc15e308a
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09346798B2
연결된 노트
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