4-Aminopyrimidine → N-(4-methoxybenzyl)pyrimidin-4-amine

반응식

CO[C:3]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:4]=1[CH2:5][NH:6][C:7]1S[N:10]=[CH:9][N:8]=1.S1C(N)=NC=N1.N1C=[CH:28][C:27](N)=NC=1>>[CH3:17][O:16][C:14]1[CH:13]=[CH:12][C:4]([CH2:5][NH:6][C:7]2[CH:28]=[CH:27][N:10]=[CH:9][N:8]=2)=[CH:3][CH:15]=1

참가 물질

반응물 3

HCID 689584-Aminopyrimidine

HCID 2902745-Amino-1,2,4-thiadiazole

HCID 57732216N-(2,4-dimethoxybenzyl)-1,2,4-thiadiazol-5-amine

생성물 1

HCID 13230138N-(4-methoxybenzyl)pyrimidin-4-amine

실험 절차

N-(4-methoxybenzyl)pyrimidin-4-amine (INTERMEDIATE AC) was prepared in a manner analogous to INTERMEDIATE A wherein 1,2,4-thiadiazol-5-amine was replaced with pyrimidin-4-amine

출처 및 근거

ORD 기록: ord-1f5d4fd2739840babae1146b4a91172e
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09346798B2

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