p-Toluenesulfonic acid monohydrate → HCID 89704942, 화합물
반응식
[C:1]([C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8](=[O:26])[CH2:9][NH:10][C:11]([CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1)=[O:12])#[N:2].O.CC1C=CC(S(O)(=O)=O)=CC=1>C(#N)C>[C:1]([C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8](=[O:26])[CH2:9][NH:10][C:11]([CH:13]1[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]1)=[O:12])#[N:2]참가 물질
4
실험 절차
To a solution of (S)-tert-butyl 4-(2-(2-cyanopyrrolidine-1-yl)-2-oxoethylcarbamoyl)piperidine-1-carboxylate (0.100 g, 0.274 mmol) in 2 ml Acetonitrile was 4-methylbenzenesulfonic acid hydrate (0.073 g, 0.384 mmol) added and the mixture was stirred for 24 h. After evaporation of the volatiles, the sample was purified by preparative HPLC to yield an reddish oil.
후처리
- additionadded