Trifluoroacetic acid → 3-Benzothiazol-2-yl-azetidine trifluoroacetate

HRID 528739노트

반응식

HRID 528739 반응식
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[S:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)[CH2:9]1)=O)(C)(C)C.[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>C(Cl)Cl>[F:24][C:23]([F:26])([F:25])[C:21]([OH:27])=[O:22].[S:13]1[C:14]2[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=[C:12]1[CH:10]1[CH2:9][NH:8][CH2:11]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 442398183-Benzothiazol-2-yl-azetidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 674587613-Benzothiazol-2-yl-azetidine trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 48 mg (166 μmol) 3-benzothiazol-2-yl-azetidine-1-carboxylic acid tert-butyl ester was added 5 mL DCM and 5 mL TFA. The resulting mixture was stirred at room temperature for 30 minutes. The solvent was evaporated to give the product as the TFA salt which was used in the next step without further purification.

후처리

  1. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-f3496f97b59944cf94bf5c815d221f4b
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346816B2

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