Trifluoroacetic acid → 3-Ethynyl-pyrrolidinium trifluoro-acetate

HRID 528776노트

반응식

HRID 528776 반응식
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]#[CH:14])[CH2:9]1)=O)(C)(C)C.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[F:18][C:17]([F:20])([F:19])[C:15]([O-:21])=[O:16].[C:13]([CH:10]1[CH2:11][CH2:12][NH2+:8][CH2:9]1)#[CH:14]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 54012212tert-Butyl 3-ethynylpyrrolidine-1-carboxylate

생성물 1

HCID 866671763-Ethynyl-pyrrolidinium trifluoro-acetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 0.85 g (4.35 mmol) 3-Ethynyl-pyrrolidine-1-carboxylic acid tert-butyl ester in 30 mL DCM was added 2 mL (26.0 mmol) TFA and stirring was continued at room temperature for 3 h. The solvents were evaporated and the residue was used for the next step without further purification.

후처리

  1. customThe solvents were evaporated
  2. customthe residue was used for the next step without further purification

출처 및 근거

ORD 기록
ord-c1eb13ada4284922a86903b907fe8526
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346816B2

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