홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Formaldehyde → (3-Ethynyl-pyrrolidin-1-yl)-[1-(7-methyl-6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]inden-10-yl)-azetidin-3-yl]-methanone

HRID 528779
노트
인쇄 미리보기

반응식

HRID 528779 반응식
[C:1]([CH:3]1[CH2:7][CH2:6][N:5]([C:8]([CH:10]2[CH2:13][N:12]([C:14]3[N:15]4[C:19]([N:20]=[C:21]5[CH2:27][CH2:26][NH:25][CH2:24][CH2:23][C:22]=35)=[CH:18][CH:17]=[N:16]4)[CH2:11]2)=[O:9])[CH2:4]1)#[CH:2].C=O.[C:30](O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C1COCC1.O>[C:1]([CH:3]1[CH2:7][CH2:6][N:5]([C:8]([CH:10]2[CH2:11][N:12]([C:14]3[N:15]4[C:19]([N:20]=[C:21]5[CH2:27][CH2:26][N:25]([CH3:30])[CH2:24][CH2:23][C:22]=35)=[CH:18][CH:17]=[N:16]4)[CH2:13]2)=[O:9])[CH2:4]1)#[CH:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 712FormaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 86667178(3-Ethynyl-pyrrolidin-1-yl)-[1-(6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]inden-10-yl)-azetidin-3-yl]-methanone

생성물 1

HCID 86667179(3-Ethynyl-pyrrolidin-1-yl)-[1-(7-methyl-6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]inden-10-yl)-azetidin-3-yl]-methanone

시약·촉매·용매 2

HCID 962
Water
용매
HCID 8028Tetrahydrofuran용매

실험 절차

To 50 mg (0.14 mmol) of (3-Ethynyl-pyrrolidin-1-yl)-[1-(6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]inden-10-yl)-azetidin-3-yl]-methanone in 2 mL of THF and 1 mL of puffer solution (pH 5) was added 11.3 μL (0.15 mmol) of formaldehyde (37% in water) and 35 mg (0.17 mmol) of sodium triacetoxyborohydride. Stirring was continued overnight, the reaction mixture diluted with 1 mL of water, filtered and purified by HPLC.

후처리

  1. filtrationfiltered
  2. custompurified by HPLC

출처 및 근거

ORD 기록
ord-7c992917dcdd4a39b29cce8e560f387a
출처 데이터셋
uspto-grants-2016_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09346816B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트