Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Iodide → 8-(4-(Methoxycarbonyl)benzyloxy)naphthalene-2-sulfonic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| 반응물 | 1-Hydroxynaphthalene-7-sulfonic acid | HCID 3022482 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 8-(4-(Methoxycarbonyl)benzyloxy)naphthalene-2-sulfonic acid | HCID 86718862 | 32.9% |
반응 단계
8-Hydroxynaphthalene-2-sulfonic acid (110 mg, 0.49 mmol), KOH (110 mg, 1.96 mmol), methyl 4-(bromomethyl)benzoate (112 mg, 0.49 mmol) and NaI (7.4 mg, 0.49 mmol) were stirred in DMF (1.0 mL) at room temperature for 1 h and then at 60° C. for 72 h. The reaction mixture was cooled to room temperature, diluted with water and purified using preparative HPLC to give the title compound (60 mg, 31%). MS(ESI−) m/z 371.3 (M−H)−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09346795B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-c1469fe480854a028fb71a34a8496dcc |
| 출처 메모 | uspto-grants-2016_05 |