Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl chloride → 1-Benzoylindoline-5-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 반응물 | 2,3-dihydro-1H-indole-5-sulfonamide | HCID 8027252 | — |
| 반응물 | 1-(Cyclohexanecarbonyl)indoline-5-sulfonamide | HCID 60698742 | — |
| 생성물 | 1-Benzoylindoline-5-sulfonamide | HCID 17681137 | 79% |
반응 단계
Following a procedure analogous to that for the synthesis of Intermediate 55, indoline-5-sulfonamide (Intermediate 54A, 100 mg, 0.50 mmol) and benzoyl chloride (64 μL, 0.56 mmol) were converted to the title compound (120 mg, 79%). 1H NMR (DMSO-d6) δ 7.70 (s, 1H), 7.65-7.60 (m, 3H), 7.57-7.49 (m, 4H), 7.24 (s, 2H), 4.07 (t, J=8.5 Hz, 2H), 3.15 (t, J=8.4 Hz, 2H); MS(ESI+) m/z 303.2 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09346795B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-e980f2a76d114151a079ad587acb17b1 |
| 출처 메모 | uspto-grants-2016_05 |