Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,4-Difluorobenzoyl chloride → 1-(3,4-Difluorobenzoyl)indoline-5-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,4-Difluorobenzoyl chloride | HCID 2724519 | — |
| 반응물 | 2,3-dihydro-1H-indole-5-sulfonamide | HCID 8027252 | — |
| 반응물 | 1-(Cyclohexanecarbonyl)indoline-5-sulfonamide | HCID 60698742 | — |
| 생성물 | 1-(3,4-Difluorobenzoyl)indoline-5-sulfonamide | HCID 71086440 | 78.8% |
반응 단계
Following a procedure analogous to that for the synthesis of Intermediate 55, indoline-5-sulfonamide (Intermediate 54A, 90 mg, 0.45 mmol) and 3,4-difluorobenzoyl chloride (69 μL, 0.54 mmol) were converted to the title compound (120 mg, 78%). 1H NMR (DMSO-d6) δ 7.60-7.21 (m, 6H), 7.01 (s, 2H), 3.85 (t, J=8.6 Hz, 2H), 2.92 (t, J=8.6 Hz, 2H); MS(ESI+) m/z 338.9 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09346795B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-c0045dcafec34760bf8796cbecb3c20c |
| 출처 메모 | uspto-grants-2016_05 |