Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Chloropicolinic acid → 1-(6-Chloropicolinoyl)indoline-5-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Chloropicolinic acid | HCID 20812 | — |
| 반응물 | 2,3-dihydro-1H-indole-5-sulfonamide | HCID 8027252 | — |
| 반응물 | 1-(2-(3,4-Dichlorophenyl)acetyl)indoline-5-sulfonamide | HCID 71061053 | — |
| 생성물 | 1-(6-Chloropicolinoyl)indoline-5-sulfonamide | HCID 86718883 | 49% |
반응 단계
Following a procedure analogous to that for the synthesis of Intermediate 64, indoline-5-sulfonamide (Intermediate 54A, 300 mg, 1.51 mmol) and 6-chloropicolinic acid (262 mg, 1.66 mmol) were converted to the title compound (250 mg, 49%). 1H NMR (DMSO-d6) δ 8.69 (d, J=2.0 Hz, 1H), 8.15-8.13 (m, 2H), 7.72-7.67 (m, 3H), 7.27 (s, 2H), 4.11 (t, J=8.4 Hz, 2H), 3.17 (t, J=8.4 Hz, 2H); MS(ESI+) m/z 338.1 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09346795B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-142ac0dc5a694d3ebc2a5f194b7fd8a5 |
| 출처 메모 | uspto-grants-2016_05 |