Butanal → HCID 71086195, 화합물

HRID 528897

반응식

[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][C:7]2[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH:16](=O)[CH2:17][CH2:18][CH3:19]>>[CH2:16]([NH:11][C:10]1[CH:12]=[CH:13][C:7]([O:6][C:5]2[CH:14]=[CH:15][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:8][CH:9]=1)[CH2:17][CH2:18][CH3:19]

참가 물질

반응물 2

HCID 261Butanal

HCID 75784-(4-Chlorophenoxy)aniline

생성물 1

HCID 71086195HCID 71086195, 화합물수율 71.6%

실험 절차

Following a procedure analogous to that for the synthesis of Intermediate 137, 4-(4-chlorophenoxy)aniline (Aldrich, 500 mg, 2.28 mmol) and butyraldehyde (230 mL, 2.50 mmol) were converted to the title compound (450 mg, 71%). 1H NMR (CDCl3) δ 7.34-7.16 (m, 2H), 6.99-6.84 (m, 4H), 6.72-6.62 (m, 2H), 4.19 (br s, 1H), 3.17 (t, J=7.2 Hz, 2H), 1.75-1.61 (m, 2H), 1.60-1.42 (m, 2H), 1.03 (t, J=7.4 Hz, 3H); MS(ESI+) m/z 275.8 (M+H)+.

출처 및 근거

ORD 기록: ord-35092ba9b88344e5aa8529ef34a9f5cc
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09346795B2

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