ethyl 4-bromo-5-methyl-1H-pyrazole-3-carboxylate → 4-bromo-N,N-dibutyl-5-methyl-1H-pyrazole-3-carboxamide

참여 물질

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Following a procedure analogous to that for the synthesis of Intermediate 1B, ethyl 4-bromo-5-methyl-1H-pyrazole-3-carboxylate (Tabrizi, M. A. et al., Bioorg. Med. Chem., 16:2419-2430 (2008)) (5.68 g, 24.4 mmol) was converted to the title compound (5.79 g, 75%). 1H NMR (CDCl3) δ 3.51 (t, J=7.4 Hz, 2H), 3.38-3.26 (m, 2H), 2.34 (s, 3H), 1.73-1.34 (m, 6H), 1.22-1.13 (m, 2H), 1.03-0.75 (m, 6H); MS(ESI+) m/z 316.2 (M+H)+.

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