ethyl 4-chloro-5-methyl-1H-pyrazole-3-carboxylate → 4-chloro-5-methyl-N,N-dipropyl-1H-pyrazol-3-amine

HRID 528953노트

반응식

HRID 528953 반응식
[Cl:1][C:2]1[C:3]([C:8](OCC)=O)=[N:4][NH:5][C:6]=1C.C[C:14]1NN=[C:16]([N:19](CCC)[CH2:20][CH2:21][CH3:22])[CH:15]=1>>[Cl:1][C:2]1[C:6]([N:19]([CH2:20][CH2:21][CH3:22])[CH2:16][CH2:15][CH3:14])=[N:5][NH:4][C:3]=1[CH3:8]

참가 물질

3

반응물 2

HCID 604759ethyl 4-chloro-5-methyl-1H-pyrazole-3-carboxylateHCID 867189125-methyl-N,N-dipropyl-1H-pyrazol-3-amine

생성물 1

HCID 710622704-chloro-5-methyl-N,N-dipropyl-1H-pyrazol-3-amine수율 61%

실험 절차

Following a procedure analogous to that for the synthesis of Intermediate 1A, 5-methyl-N,N-dipropyl-1H-pyrazol-3-amine (400 mg, 2.21 mmol) was converted to the title compound (290 mg, 61%). 1H NMR (CDCl3) δ 3.20-3.16 (m, 4H), 2.18 (s, 3H), 1.55 (sxt, J=7.5 Hz, 4H), 0.88 (t, J=7.4 Hz, 6H); MS(ESI+) m/z 216.1 (M+H)+.

출처 및 근거

ORD 기록
ord-da82e86fc25a4b45b971e4b305f81ba1
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346795B2

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