N-[N-(benzyloxycarbonyl)-N-methylvalyl]-L-aspartic acid di-tert-butyl ester → N-(N-methyl-L-valyl)-L-aspartic acid di-tert-butyl ester

HRID 529213노트

반응식

HRID 529213 반응식
[C:1]([O:5][C:6](=[O:35])[C@H:7]([CH2:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[NH:8][C:9](=[O:26])[C@H:10]([CH:23]([CH3:25])[CH3:24])[N:11](C(OCC1C=CC=CC=1)=O)[CH3:12])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:35])[C@H:7]([CH2:27][C:28]([O:30][C:31]([CH3:32])([CH3:34])[CH3:33])=[O:29])[NH:8][C:9](=[O:26])[C@H:10]([CH:23]([CH3:25])[CH3:24])[NH:11][CH3:12])([CH3:2])([CH3:3])[CH3:4]

참가 물질

4

반응물 1

HCID 86714692N-[N-(benzyloxycarbonyl)-N-methylvalyl]-L-aspartic acid di-tert-butyl ester

생성물 1

HCID 86714693N-(N-methyl-L-valyl)-L-aspartic acid di-tert-butyl ester수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of the compound (0.91 g, 1.8 mmol) obtained in step 1 in ethanol (40 ml) was added a catalytic amount of 10% palladium/carbon, and the mixture was stirred for 3 hours under a hydrogen atmosphere. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (0.66 g, 1.8 mmol, 99%).

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-79b3082c4df14b84bd64888bd9a6de48
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346821B2

반응 노트

불러오는 중…