3-(Azidomethyl)furan → HCID 178479124, 화합물

HRID 529899

반응식

HRID 529899 반응식
[ClH:1].[CH2:2]([C:6]1[N:7]=[C:8]([NH2:11])[NH:9][CH:10]=1)[CH2:3][C:4]#[CH:5].[N:12]([CH2:15][C:16]1[CH:20]=[CH:19][O:18][CH:17]=1)=[N+:13]=[N-:14]>>[ClH:1].[O:18]1[CH:19]=[CH:20][C:16]([CH2:15][N:12]2[CH:5]=[C:4]([CH2:3][CH2:2][C:6]3[N:7]=[C:8]([NH2:11])[NH:9][CH:10]=3)[N:14]=[N:13]2)=[CH:17]1

참가 물질

3

반응물 2

HCID 230684473-(Azidomethyl)furanHCID 178441359HCID 178441359, 화합물

생성물 1

HCID 178479124HCID 178479124, 화합물수율 54%

실험 절차

4-But-3-ynyl-1H-imidazol-2-ylamine hydrochloride (0.066 g, 0.384 mmol) was reacted with 3-azidomethyl-furan (0.057 g, 0.461 mmol) following the general procedure for click reactions outlined above to produce 4-[2-(1-Furan-3-ylmethyl-1H-[1,2,3]triazol-4-yl)-ethyl]-1H-imidazol-2-ylamine hydrochloride (0.061 g, 54%) as a pale yellow solid. 1H NMR (300 MHz, CD3OD) δ 7.70 (s, 1H), δ 7.61 (s, 1H), δ 7.46 (s, 1H), δ 6.42 (s, 1H), δ 6.38 (s, 1H), δ 5.41 (s, 2H), δ 2.95 (t, 2H), δ 2.83 (t, 2H) ppm; 13C (75 MHz, CD3OD) δ 146.3, 144.2, 141.6, 141.5, 126.5, 122.3, 120.2, 109.9, 109.1, 44.8, 24.2, 23.9 ppm; HRMS (ESI) calcd for C12H14N6O (M+) 259.1301. found 259.1306.

출처 및 근거

ORD 기록
ord-8f11b5b424fd414fbaefc543ece6d034
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09351491B2

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