3-(Azidomethyl)furan → HCID 178479137, 화합물

HRID 529905노트

반응식

HRID 529905 반응식
[ClH:1].[CH2:2]([C:7]1[N:8]=[C:9]([NH2:12])[NH:10][CH:11]=1)[CH2:3][CH2:4][C:5]#[CH:6].[N:13]([CH2:16][C:17]1[CH:21]=[CH:20][O:19][CH:18]=1)=[N+:14]=[N-:15]>>[ClH:1].[O:19]1[CH:20]=[CH:21][C:17]([CH2:16][N:13]2[CH:6]=[C:5]([CH2:4][CH2:3][CH2:2][C:7]3[N:8]=[C:9]([NH2:12])[NH:10][CH:11]=3)[N:15]=[N:14]2)=[CH:18]1

참가 물질

3

반응물 2

HCID 230684473-(Azidomethyl)furanHCID 1784422514-Pent-4-ynyl-1H-imidazol-2-ylamine hydrochloride

생성물 1

HCID 178479137HCID 178479137, 화합물수율 58.1%

실험 절차

4-Pent-4-ynyl-1H-imidazol-2-ylamine hydrochloride (0.063 g, 0.340 mmol) was reacted with 3-azidomethyl-furan (0.050 g, 0.406 mmol) following the general procedure for click reactions outlined above to produce 4-[3-(1-Furan-3-ylmethyl-1H-[1,2,3]triazol-4-yl)-propyl]-1Himidazol-2-ylamine hydrochloride (0.061 g, 58%) as a pale yellow solid. 1H NMR (300 MHz, CD3OD) δ 7.70 (s, 1H), δ 7.56 (s, 1H), δ 7.41 (s, 1H), δ 6.44 (s, 1H), δ 6.35 (s, 1H), δ 5.35 (s, 2H), δ 2.65 (t, 2H), δ 2.45 (t, 2H), δ 1.86 (m, 2H) ppm; 13C NMR (75 MHz, CD3OD) δ 147.3, 147.3, 144.2, 141.6, 127.2, 122.1, 120.2, 109.9, 108.8, 44.7, 27.8, 24.2, 23.6 ppms; HRMS (ESI) calcd for C13H16N6O (M+) 272.1458. found 272.1462.

출처 및 근거

ORD 기록
ord-c5256d82de3140f1b77f015be48fe705
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09351491B2

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