3-Hydroxybutyric Acid → (-)-3-t-Butyldimethylsilyloxybutyric acid

HRID 529970노트

반응식

HRID 529970 반응식
[OH:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].[CH3:8][C:9]([Si:12](Cl)([CH3:14])[CH3:13])([CH3:11])[CH3:10]>C(Cl)Cl>[C:9]([Si:12]([CH3:14])([CH3:13])[O:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5])([CH3:11])([CH3:10])[CH3:8]

참가 물질

4

반응물 2

HCID 4413-Hydroxybutyric AcidHCID 28928tert-Butyldimethylsilyl chloride

생성물 1

HCID 13712781(-)-3-t-Butyldimethylsilyloxybutyric acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-Hydroxy-butyric acid (500 mg, 4.8 mmol) is dissolved in a mixture of TBSCl (1.5 g, 10.1 mmol) in dry DCM (48 mL). The resulting mixture is stirred overnight at room temperature. The resulting suspension is then filtered and the obtained residues are washed with DCM, then stirred in Et2O and filtered. The obtained filtrate is evaporated to give the desired product that is used as such.

후처리

  1. filtrationThe resulting suspension is then filtered
  2. washthe obtained residues are washed with DCM
  3. stirringstirred in Et2O
  4. filtrationfiltered
  5. customThe obtained filtrate is evaporated

출처 및 근거

ORD 기록
ord-8ecca6f1a18d463d89f9800f9d024cbd
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09351955B2

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