Chlorosuccinimide → 2-(5-(3-Chloropyrazolo[1,5-a]pyridin-2-yl)pyridin-3-yl)propan-2-ol

HRID 530020노트

반응식

HRID 530020 반응식
[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]2=[CH:3][C:2]=1[C:10]1[CH:11]=[C:12]([C:16]([OH:19])([CH3:18])[CH3:17])[CH:13]=[N:14][CH:15]=1.[Cl:20]N1C(=O)CCC1=O>C(#N)C>[Cl:20][C:3]1[C:2]([C:10]2[CH:11]=[C:12]([C:16]([OH:19])([CH3:17])[CH3:18])[CH:13]=[N:14][CH:15]=2)=[N:1][N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=12

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 894632872-(5-(Pyrazolo[1,5-a]pyridin-2-yl)pyridin-3-yl)propan-2-ol

생성물 1

HCID 894716412-(5-(3-Chloropyrazolo[1,5-a]pyridin-2-yl)pyridin-3-yl)propan-2-ol

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of the title compound from Example 2 Step A (0.099 g, 0.391 mmol) and N-chlorosuccinimide (0.063 g, 0.469 mmol) in acetonitrile (1.95 ml) was stirred at room temperature for 2 hours. The reaction was then concentrated under reduced pressure, diluted with dichloromethane, washed with saturated aqueous sodium chloride solution, dried over MgSO4, filtered and concentrated under reduced pressure.

후처리

  1. concentrationThe reaction was then concentrated under reduced pressure
  2. additiondiluted with dichloromethane
  3. washwashed with saturated aqueous sodium chloride solution
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f562f1dfda3e47aa9c76622bbff42f6c
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09351973B2

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