Pyridine → HCID 43346898, 화합물

HRID 530334

반응식

HRID 530334 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([Cl:9])[CH:3]=1.N1C=CC=CC=1.[Cl:16][CH2:17][CH2:18][C:19](Cl)=[O:20]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:19](=[O:20])[CH2:18][CH2:17][Cl:16])=[C:4]([Cl:9])[CH:3]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 693643-Chloropropionyl chlorideHCID 6101694-Bromo-2-chloroaniline

생성물 1

HCID 43346898HCID 43346898, 화합물수율 90%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-bromo-2-chloro-phenylamine (32 g, 0.15 mol) and pyridine (13.45 g, 0.17 mol) in DCM (200 mL) was added 3-chloropropionyl chloride (21.65 g, 0.17 mol) dropwise at 15° C. After stirring at room temperature for 1 hr, the mixture was washed with water and then 2 N aq. hydrochloric acid. The organic layer was dried over anhy. Na2SO4, filtered, and concentrated in vacuo to afford the title compound (10.9 g, 90% yield) as a white solid.

후처리

  1. washthe mixture was washed with water
  2. customThe organic layer was dried over anhy
  3. filtrationNa2SO4, filtered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-352743b736314e55b9a764ea8898533f
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353081B2

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