1(3H)-Isobenzofuranone, 3-bromo- → HCID 178440074, 화합물

HRID 53039

반응식

HRID 53039 반응식
[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:13][CH2:14][CH3:15])[NH:8][C:9]=1[C:10]([OH:12])=[O:11])([CH3:4])[CH3:3].Br[CH:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:19](=[O:20])[O:18]1>>[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:13][CH2:14][CH3:15])[NH:8][C:9]=1[C:10]([O:12][CH:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:19](=[O:20])[O:18]1)=[O:11])([CH3:4])[CH3:3]

참가 물질

3

반응물 2

HCID 962181(3H)-Isobenzofuranone, 3-bromo-HCID 178440085HCID 178440085, 화합물

생성물 1

HCID 178440074HCID 178440074, 화합물수율 94.8%

실험 절차

Following a procedure similar to that described in Preparation 31, but using 1.06 g of 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid [prepared as described in Preparation 22(i)] and 1.15 g of 3-bromophthalide, 1.63 g of the title compound were obtained as an amorphous solid.

후처리

  1. customthat described in Preparation 31

출처 및 근거

ORD 기록
ord-26302c2567c549ef8a5f2b6afc555040
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616599

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